解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Zinc finger protein 307 (ZNF307) is a new Krüppel-associated box zinc-finger protein gene and a member of the zinc-finger family of transcriptional factors. Notably, the role of ZNF307 and its underlying mechanisms involved in hepatocarcinogenesis are poorly investigated. In the present study, we found that the expres...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5868
更新日期:2017-10-01 00:00:00
abstract::MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed t...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5854
更新日期:2017-10-01 00:00:00
abstract::Gastric cancer (GC) is one of the most common malignancies, and is the second leading cause of cancer-related deaths worldwide. Macrophages infiltrated in the tumor microenvironment (TME) called tumor-associated macrophages (TAMs) are key orchestrators in TME. In GC, it has been reported that infiltration of TAMs is a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5877
更新日期:2017-10-01 00:00:00
abstract::Triosephosphate isomerase (TPI) is highly expressed in many types of human tumors and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and malignant function in gastric cancer (GC) have not been well defined. The present study aimed to examine TPI expression in GC ti...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5846
更新日期:2017-09-01 00:00:00
abstract::Prostate cancer (PCa) is a leading cause of death among men. The dysregulation of metabolism and autophagy contributes to the progression of PCa. The transcription factor specificity protein 1 (Sp1) is implicated in the regulation of metabolism and autophagy. We confirmed that Sp1 is overexpressed in castration-resist...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5852
更新日期:2017-09-01 00:00:00
abstract::Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechan...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5818
更新日期:2017-09-01 00:00:00
abstract::The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matched controls, to influence tubule formation and modulate angiogenesis i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5803
更新日期:2017-09-01 00:00:00
abstract::MicroRNAs (miRNAs) play a vital role in tumour biological and pathologic processes. In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells. Ectopic expression of miR-216b inhibite...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5824
更新日期:2017-09-01 00:00:00
abstract::Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5787
更新日期:2017-08-01 00:00:00
abstract::This study analyzed microRNA (miRNA) and mRNA expression profiles and investigated the biological characteristics of ESCC by using invasion and cytotoxicity cell models. miRNA profiles were evaluated through miRNA microarray. Transwell chamber and nedaplatin (NDP) were used to construct invasion and cytotoxicity cell ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5776
更新日期:2017-08-01 00:00:00
abstract::Cervical cancer is the second most common gynecological malignancy. The mechanisms of the genesis and progression of cervical cancer are complicated and not thoroughly understood. DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer and hepatocellular cancer....
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5721
更新日期:2017-08-01 00:00:00
abstract::MicroRNAs are short RNAs that play a crucial role in all biological processes through post-transcriptional regulation for protein-coding genes and inducing mRNA degradation. Hepatitis B virus infection has been considered as a major risk factor in hepatocellular carcinoma, further research indicates that hepatitis B v...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2017.5716
更新日期:2017-08-01 00:00:00
abstract::It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5726
更新日期:2017-08-01 00:00:00
abstract::Vasohibin-1 (VASH1) has recently been isolated as a novel inhibitor of angiogenesis. Several studies have demonstrated that VASH1 plays important roles in tumor angiogenesis but the role of this angiogenic inhibitor in renal cell carcinoma (RCC) has not been elucidated. We previously reported that VASH1 expression is ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5746
更新日期:2017-08-01 00:00:00
abstract::Recent studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in many types of human malignant cancers. However, the function of lncRNAs in benign tumors remains poorly understood. In the present study, to explored the potential roles of lncRNAs in benign epithelial ovarian cysts (BEOCs) which commonly...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5741
更新日期:2017-08-01 00:00:00
abstract::MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma prog...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5740
更新日期:2017-08-01 00:00:00
abstract::miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small c...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5755
更新日期:2017-08-01 00:00:00
abstract::Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor, which was confirmed as a tumor suppressor gene in colorectal cancers. KLF4 inhibits colorectal cancer cells proliferation through upregulating p21WAF1/Cip1 and downregulating cyclin D1. We firstly reported that N-Myc downstream regulated gene 2 (NDRG2...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5736
更新日期:2017-08-01 00:00:00
abstract::Cell cycle control is a promising target in cancer treatments, and some small-molecule cyclin-dependent kinase (CDK) inhibitors have exhibited clinical effectiveness. However, no biomarkers predictive of efficacy have been developed. Recent studies have revealed that CDK inhibitor (CKI) proteins, such as p27 and p16, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5684
更新日期:2017-07-01 00:00:00
abstract::E1A binding protein P300 (EP300), tumor protein P53 (TP53) and BCL2 associated X, apoptosis regulator (BAX) genes encode proteins which cooperate to regulate important cellular processes. The present study aimed to determine the expression levels of EP300, TP53 and BAX in colorectal cancer (CRC) and to investigate the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5687
更新日期:2017-07-01 00:00:00
abstract::Human Pinx1 protein, associated with shelterin proteins, is widely revealed as a haploinsufficient tumor suppressor. Growing evidence has manifested the deregulation of PinX1 in distinct cancers. Nonetheless, the loss status of PinX1 and its diagnostic, prognostic and clinicopathological significance in Basal-like bre...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5696
更新日期:2017-07-01 00:00:00
abstract::The activation of receptor tyrosine kinases (RTKs) results in cellular effects including cell proliferation, survival, migration and invasion; RTKs also play an important role in tumourigenesis. It has been reported that EGFR signalling controls the migration of oral squamous cell carcinoma (OSCC) SAS and HSC3 cells b...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5587
更新日期:2017-06-01 00:00:00
abstract::Tripartite motif containing 28 (TRIM28) is a universal corepressor for Kruppel‑associated box zinc finger proteins. In our previous study, it was shown that expression of TRIM28 is upregulated in non‑small cell lung cancer (NSCLC) cell lines and tissues. Here, we demonstrated that the stable silencing of TRIM28 expres...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5638
更新日期:2017-06-01 00:00:00
abstract::CXC chemokine receptor 4 (CXCR4) is associated with poor clinical outcomes and decreased survival in hepatocellular carcinoma (HCC). In the present study, we targeted CXCR4 by CRISPR/Cas9 in HepG2 cells and observed the effects both in vitro and in vivo. The results indicated that after targeting CXCR4 the expression ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5601
更新日期:2017-06-01 00:00:00
abstract::Ultraviolet (UV) radiation is the primary risk factor underlying photoaging and photocarcinogenesis. Mounting research has focused on the role of DNA damage response pathways in UV-induced double-strand break (DSB) repair. In the present study, we hypothesized that UVA-induced aberrant progerin upregulation may advers...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5603
更新日期:2017-06-01 00:00:00
abstract::The roles and mechanisms of mini-chromosome maintenance complex component 7 (MCM7) amplification and overexpression in esophageal carcinogenesis were investigated. By analyzing the TCGA datasets, we found that MCM7 was amplified in approximately 12% of esophageal squamous cell carcinomas (ESCCs), and in more than 4% o...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5614
更新日期:2017-06-01 00:00:00
abstract::Semaphorin 3A (SEMA3A), a secretory protein, is a founding member of the semaphorin family and functions in both the biological behavior of tumor cells and the modulation of tumor-associated macrophages. However, the role of SEMA3A in hepatocellular carcinoma (HCC) is still not well established. In the present study, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5616
更新日期:2017-06-01 00:00:00
abstract::Miconazole (MIC), an antifungal agent, diplays anti‑tumorigenic activity in various types of human cancers, including bladder cancer, yet its mechanism of antitumor action is not well understood. In the present study, we demonstrated that, in a cell viability assay, MIC had a cytotoxic effect on human T24, J82 and TSG...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5608
更新日期:2017-06-01 00:00:00
abstract::Though patients with EGFR mutations are initially responsive to EGFR-tyrosine kinase inhibitors (TKIs), most tumors ultimately acquire resistance to EGFR-TKIs. The most frequently reported mechanism is EGFR T790M mutation. In this study, using a droplet digital PCR (ddPCR) system, we assessed optimal conditions for a ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5567
更新日期:2017-05-01 00:00:00
abstract::PFN2 is an invasion promoter in several cancers including lung cancer. However, the probable effects and underlying mechanisms of PFN2 in tumor cell epithelial-mesenchymal-transition (EMT) of non-small cell lung cancer (NSCLC) remain poorly understood. The protein and mRNA levels of PFN2 in human bronchial epithelial ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5566
更新日期:2017-05-01 00:00:00
abstract::MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lu...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5548
更新日期:2017-05-01 00:00:00
abstract::Ovarian cancer is the leading cause of death among malignancies of the female reproductive system. The 5-year survival rates of ovarian cancer (OC) patients are very poor as a result of recurrent disease and emergence of drug resistance; thus, studies to find predictive markers and factors for drug resistance are ongo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5534
更新日期:2017-05-01 00:00:00
abstract::The purpose of this study was to examine the effects of irradiation by 125I seeds in human lung cancer xenograft model and to determine the underlying mechanisms involved, with a focus on angiogenesis. A group of 40 mice bearing A549 lung adenocarcinoma xenografts was randomly separated into 4 groups: control group (n...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5521
更新日期:2017-05-01 00:00:00
abstract::Activation of C-C chemokine receptor type 7 (CCR7) has been demonstrated to mediate the occurrence and progression of non-small cell lung cancer (NSCLC). However, the potential therapeutic role of CCR7 inhibition in NSCLC is still obscure. Thus, the present study was conducted to investigate the molecular mechanism un...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5524
更新日期:2017-05-01 00:00:00
abstract::Triple-negative breast cancer is a highly aggressive type of mammalian carcinoma. It is defined by a rather weak expression of estrogen-, progesterone- and Her2-receptor, and is thus difficult to treat, resulting in low disease-free and overall survival rates of the affected patients. Hence it is important to find new...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5512
更新日期:2017-05-01 00:00:00
abstract::Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the di...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5487
更新日期:2017-04-01 00:00:00
abstract::Taxol (paclitaxel) and vinblastine (VBL) are both efficacious chemotherapeutic agents that target the microtubules of tumor cells, but each functions in a mutual antagonistic manner. Op18/stathmin is a small molecular phosphoprotein which promotes depolymerization of microtubules. Non-small cell lung cancer (NSCLC) NC...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5469
更新日期:2017-04-01 00:00:00
abstract::A growing body of evidence suggests that microRNA-365 (miR-365) played crucial role in the initiation and development of many types of cancers. However, the biological role of miR-365 in human glioma remains unclear. Herein, the aims of this study were to investigate the role and underlying mechanisms of miR-365 in gl...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5458
更新日期:2017-04-01 00:00:00
abstract::The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5449
更新日期:2017-04-01 00:00:00
abstract::Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2017.5473
更新日期:2017-04-01 00:00:00